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First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies

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While IGF-1 plays a role in muscle repair and satellite cell activation, outcomes depend on nutrition, recovery, hormonal balance, and overall health

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Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians