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Strikingly, estrogen deprivation was shown to be the principal mediator of impaired wound healing in the elderly population when a microarray study revealed that 78% of genes differentially expressed between wounds from young and aged men were estrogen-regulated, while only 3% were related to intrinsic aging (Hardman and Ashcroft, 2008

doi:10.1016/j.jtos.2020.08.008 6

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach

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