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Why GLP-1 Side Effects Fade as Your Body Adapts Your gastrointestinal tract and central nervous system undergo a gradual rebalancing process called tachyphylaxis, in which receptors become less sensitive to the medication's stimulus over time

These results provide a foundation for the further clinical development of tirzepatide in the Chinese population

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But heres some important context

Its not like I dont wanna it at all either which is perfect to be able to maintain muscle mass while also losing body fat