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Immunohistochemistry techniques have demonstrated neuropeptide Y in the cytotrophoblast and intermediate trophoblast cells.230 Maternal levels of neuropeptide Y rise in early pregnancy and remain elevated at term, increasing further during labor, but not in women who are delivered by cesarean section.231 Neuropeptide Y levels fall precipitously after delivery.231 Maternal plasma levels are greater in women with preeclampsia than in pregnant controls, which suggests that neuropeptide Y may play a role in the development of pregnancy-induced hypertension.232 Neuropeptide Y receptors have been detected in the placenta, and the peptide has been reported to stimulate release of CRH from placental cells.230, 233 Inhibins, Activins, and Follistatin Inhibin and activins are glycoproteins that belong to the transforming growth factor- family and participate in fine-tuning the hypothalamic-pituitary-gonadal secretion of gonadotropins.234 Inhibins and activins are encoded by three different genes ( , A

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doi: 10.1097/YCO.0b013e3282f29841 162 NemetsHNemetsBApterABrachaZBelmakerRH

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