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The metabolic impacts of GLP-1RAs go beyond their conventional functions, as they operate through a variety of interconnected systems linking the gastrointestinal (GI) tract, central nervous system (CNS), and immune system [5-7]
"We start these drugs in very low doses and titrate up while while watching patients very carefully for nausea, for vomiting, for weight loss which is too rapid, which is over one to two pounds of weight on average per week," Apovian told ABC News
Cell 16 , 20282038 (2005)
aRWD: real-world data from cohort or registry studies (electronic health records, insurance-claims databases), bSRS: adverse drug reaction evidence from case reports and spontaneous-reporting systems, such as the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and World Health Organization (WHO) VigiBase
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