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In a placebo-controlled clinical trial , glutathione IV therapy showcased mild improvements with tremors and rigidness, potentially improving the quality of life in those suffering from this disease

Future studies are needed, particularly in clearly defined organ-involved settings such as lupus nephritis, to combine single-cell analysis, spatial transcriptomics, and metabolic flux analysis in order to distinguish the pathogenic driving role of metabolic alterations from their role as accompanying biomarkers

Evidence was graded as Class II (probably effective) per American Academy of Neurology guidelines [5][25]

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