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Cyclisation restricts backbone conformational freedom and confers marked resistance to proteolysis relative to linear analogues, which is why melanotan 2 became a standard reference agonist rather than a research curiosity

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We showed that MeCbl downregulated the activity of Erk1/2 and promoted the expression of the myelin basic protein in SCs

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Sublingual compounded versions have not been evaluated through the same FDA approval process