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Subsequent peer-reviewed preclinical studies have examined its use as a tool compound for investigating NNMT enzyme activity in adipose, liver, and skeletal muscle cell-based research models under controlled laboratory conditions

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Tesofensine should be dosed at the start of your waking period not immediately before sleep because its noradrenergic effects peak 34 hours post-administration and can interfere with sleep architecture even in individuals accustomed to shift work