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Understanding the mechanisms behind this muscle loss, the factors that influence it, and evidence-based strategies to preserve muscle function helps patients and clinicians optimize treatment outcomes while maintaining strength and functional independence throughout therapy
Melatonin has also been implicated in the suppression of autophagy under various stress conditions, including nicotine exposure, serum starvation, excessive autophagy, and unpredictable stress, possibly through modulation of miR-15a-5p, PI3K/Akt/mTOR, and eIF2/ATF4 pathways (Wang et al., 2018
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