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However, people taking Ozempic should watch for the following symptoms of blood clots: Recurring pain or discomfort in one area of the body Redness or tenderness in the affected area Unexplained pain in the arms, legs, or other parts of the body People taking Ozempic should also closely monitor themselves for the potentially serious symptoms of DVT and PE: Deep vein thrombosis (DVT): Swelling, pain, and tenderness in the affected area, often the leg Pulmonary embolism (PE): Sudden shortness of breath, chest pain, sweating, and rapid heart rate How Might Ozempic Cause Blood Clots