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doi: 10.1016/j.cbi.2019.06.001 186 SallesGNCalioMLHolscherCPacheco-SoaresCPorcionattoMLoboAO

Avoid drinking large quantities of fluid immediately before or during meals, as this can contribute to uncomfortable fullness

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

TRIUMPH-2 Results in Detail TRIUMPH-2 enrolled 1,152 adults with obesity or overweight and type 2 diabetes, randomized to retatrutide 4mg, 9mg, 12mg, or placebo over 80 weeks a 1:1:1:1 design

After filtering on samples passing SomaLogic quality control (RowCheck = =TRUE) and selecting aptamers targeting human proteins, the remaining data covering 7,289 aptamers were log 10 transformed and, for each aptamer, all measurements standardized using the mean and standard deviation (s.d.) of samples obtained at baseline