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Physiologically, it can bind to GLP-1 receptor on pancreatic beta cells through endocrine, activate adenylate cyclase, increase intracellular cAMP levels, promote glycolysis and ATP production, and enhance glucose-stimulated insulin secretion
We recommend following up these patients closely to develop better recommendations for management based on long-term outcome data for example by cardiovascular screening every 25 years and assessments of quality of life by questionnaires
The connection is indirect but biologically meaningful
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