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A randomized, double-blind, placebo-controlled trial in 28 older women (ages, 65-70 years) found no effect of L-carnitine supplementation (1.5 g/day for 24 weeks) on serum pro-inflammatory cytokine concentrations, body mass and composition (lean [fat-free] mass and skeletal muscle mass), or measures of skeletal muscle strength (123)

B12 deficiency more common than most people realize, particularly in people over 40 and those with certain dietary patterns can significantly impair energy and metabolic function

The included amounts are based on official nutritional recommendations and are designed for daily intake

Animal-to-human amount translation is not straightforward and requires allometric scaling, and human pharmacokinetics, safety, and efficacy remain uncharacterized in published literature

Improvements in skin and connective tissue : Increases in growth hormone and related growth factors can enhance collagen turnover and skin texture, leading to smoother, more vibrant skin