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For patients without absorption disorders, high-dose oral B12 supplements (1,000-2,000 mcg daily) have been shown to be comparably effective to injections in correcting mild to moderate deficiency

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The process of glucuronic acid conjugation usually terminates the pharmacological activity of drugs but in some cases drug is converted into an active form

Notably, more than 95% of Kupffer cells expressed TIM4, a marker of embryonically-derived Kupffer cells 25 , indicating that repopulation by monocyte-derived macrophages (which are typically TIM4 ) was minimal under these conditions (Supplementary Fig

AOD-9604 isn't FDA-approved as a drug