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There is no direct drug interaction between linaclotide and Wegovy as they use different metabolic pathwayslinaclotide acts locally in the gut with minimal absorption, whilst semaglutide is metabolised systemically by proteolytic enzymes

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If you become pregnant or plan to, stop GLP-1 therapy and contact your provider immediately

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Tirzepatide is a dual GIP and GLP-1 receptor agonist, while semaglutide is solely a GLP-1 receptor agonist