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Simultaneously, these drugs suppress glucagon release , a hormone that raises blood glucose, thereby preventing excessive glucose production by the liver

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Downstream signaling involves PI3K/AKT, MAPK/ERK, and PLC- pathways, which are well-characterized drivers of synaptogenesis, dendritic spine maturation, and neuronal survival

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Cancer Prev Res (Phila) 3(2):160169 Straume O, Akslen LA (1997) Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma