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In summary, the history of GLP-1 drugs is a remarkable journey from an obscure gut peptide to a cornerstone of modern metabolic therapy a journey marked by scientific ingenuity, translational research breakthroughs, and profound clinical benefit for millions of patients

Collins FW et al

The study concluded that MK-677 can reverse diet-induced nitrogen depletion, suggesting a role in the treatment of catabolic entities

10.2337/db16-1009 Summary Keywords GLP-1 receptor agonist, molecular mechanisms, gut microbiota, multi-organ protection, therapeutic repurposing Citation Gong B, Li C, Shi Z, Wang F, Dai R, Chen G and Su H (2025) GLP-1 receptor agonists: exploration of transformation from metabolic regulation to multi-organ therapy

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