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Luteinizing hormone climbed 80%, and follicle-stimulating hormone increased by 72.2%, indicating that the entire hypothalamic-pituitary-gonadal axis was reactivating naturally, waking up from the suppression caused by excess adipose tissue
Google Scholar 4 Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al
These mechanisms contribute to the substantial weight loss observed in clinical trials, with patients in the STEP 1 trial losing an average of 14.9% of body weight (compared to 2.4% with placebo) on the 2.4 mg weekly dose used for obesity management
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Instead, they should explain that weight loss stabilization and slowed glycemic improvement are expected parts of chronic disease management that often require reassessment and individualized care planning
