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The mean change in body weight from baseline to week 104 was 15.2% in the semaglutide group ( n = 152) versus 2.6% with placebo ( n = 152), for an estimated treatment difference of 12.6 %-points (95% confidence interval, 15.3 to 9.8

Because it does not activate the hGH receptor (fully) and does not elevate IGF-1 in human trials, it avoids many of the growth-hormone-related side effects (such as insulin resistance) seen with full hGH therapy

Recent animal studies have demonstrated its capacity to enhance cartilage regeneration in osteoarthritis models, suggesting potential therapeutic value for degenerative joint conditions