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Few data are available regarding the safety of combining MS DMTs with other immunomodulatory therapies, presenting a challenge for the treatment of people with MS who have comorbid systemic autoimmune disorders or cancers that require immunomodulatory therapy
For example, specific gene polymorphisms have been linked to variations in depressive symptoms in response to major life stress, underscoring the important role genetic factors play in the disorders pathogenesis [302, 303]
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George Perry is an Editor-in-Chief of the Journal of Alzheimers Disease but was not involved in the peer-review process
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