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Oral progesterone in HRT serves a critical safety function: it protects the uterine lining (endometrium) from the effects of unopposed estrogen, which can lead to endometrial hyperplasia and potentially cancer

Model 3: adjusted for other variables including BMI, blood pressure, lipid profile, renal function, osteocalcin, vitamin D levels, HbA1c, statin use, antihypertensive medication use, and smoking status

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Insulin in the brain: sources, localization and functions