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We show here that glutathione is a reservoir for synaptic glutamate, the excitatory neurotransmitter in the central nervous system
None of the studies had used a structured sampling frame for case ascertainment making them prone to selection bias
Compared with VDAC blockade, USP30 inhibition benefits from enzymatic tractability and measurable pharmacodynamic readouts, although its efficacy is still likely to depend on residual integrity of PINK1/Parkin-associated quality control pathways in the target cells
GHK-Cu stimulates collagen synthesis, promotes extracellular matrix remodeling, and reduces oxidative stress, as documented in the preclinical literature
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