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[1] According to the researchers TGF-beta1 induction of angiogenesis requires a rapid and transient apoptotic effect mediated by VEGF/VEGFR2. AHK-Cu, by enhancing levels of the Vascular Endothelial Growth Factor, may possibly activate fibroblasts and endothelial cells
This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases
Collagen also exhibits an affinity for water, and it appears to hydrate the skin cells and Extracellular Matrix when it penetrates the skin barrier
Studies have suggested that AHK-Cu may also lead to the formation of new hair follicles by promoting new blood vessels and improving blood supply to existing hair follicles
PMCID: PMC2749291
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