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There is no pill, supplement, or dietary change that lowers B12. You cannot flush excess B12 by drinking water or eating differently

Both matter for choosing between oral and injectable forms

The initial inflammatory modulation begins within the first one to two weeks, but the functional changes, including improved flexibility, reduced global stiffness, and better circulation, accumulate over four to eight weeks as the compounds systemic effects build through repeated dosing

anyone can develop a deficiency of vitamin B12, some population groups suffer more easily

Although a diagnosis of diabetes does not necessarily mean that you will have a B12 deficiency, it does make you more susceptible under certain circumstances