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Food and Drug Administration for any medical, therapeutic, or diagnostic use

JAMA Neurol (2013) 70(9):11779.10.1001/jamaneurol.2013.3197 46 AvulaSParikhSDemarestSKurzJGropmanA

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Short-term GHK-Cu use (weeks to few months) typically shows benefits gradually declining toward baseline over 2-4 months post-discontinuation as newly synthesized collagen undergoes normal degradation without replacement at treatment-stimulated rates

Native Americans were chewing on the bark of the white willow for pain relief and fever reduction long before the barks salicin led to the invention (and, later, FDA approval) of aspirin