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The most common side effects were gastrointestinal: nausea, diarrhoea, and vomiting, which occurred most frequently during the dose-escalation phase and were generally rated as mild to moderate
DPP-4 degrades GLP-1 (7-36) into the non insulinotropic GLP-1 (9-36) (some studies suggest it may have weak insulinotropic activity)
The feeling of fullness can extend to liquids, and mild, persistent nausea can make the thought of drinking unappealing
Still, medications like retatrutide represent an exciting evolution in medical weight loss," says Burns, "but sustainable success comes from a comprehensive strategy that includes nutrition, exercise and a healthy lifestyle.
Liposuction or bariatric surgery provides immediate results but needs longer recovery
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