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Because of these roles, researchers have studied choline supplementation for preventing cognitive decline and improving memory in people of all ages.6 Observational research supports the link: in the Framingham Offspring cohort, higher choline intake correlated with better memory and a reduced risk of dementia over 10 years.31 Clinical trials have also zoomed in on forms that more readily cross the blood-brain barrier citicoline (CDP-choline) and alpha-GPC

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PMID 20061218