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If heartburn persists despite these measures, a medication review may be necessary to consider dose adjustment or alternative diabetes treatments

Biochemistry and molecular cell biology of diabetic complications

This speed can be critical, especially for individuals with poorly controlled glucose levels

Without adequate protein intake and resistance training, a significant share of the weight lost on a GLP-1 will be lean mass rather than fat particularly concerning for older adults where sarcopenia is already a risk

Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92