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Long-term treatment with palmitate, a type of long-chain saturated fatty acid, can disrupt the rhythmic secretion of GLP-1 by suppressing the expression of the Bmal1 clock gene [141]
10.1016/j.celrep.2021.109235 508 XuS.TuoQ
NICE recommends lifestyle modifications and PDE5 inhibitors such as sildenafil, tadalafil, vardenafil, and avanafil as first-line pharmacological treatments
