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We observed dysregulation of multiple transcription factors in the hypothalamus that are critical for various metabolic functions (Figure 4A), including impaired leptin signaling, a hallmark of BBS (24), and disrupted cholecystokinin (CCK) signaling

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[24] [26] Paradoxically, whilst total oestrogen might decrease with fat loss, the hormonal profile may become more balanced and physiologically appropriate

To mitigate these issues and their effects on your weight loss journey, it pays to be proactive

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