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Mice that underwent MCAO had a significantly higher NDS score than sham mice

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One particularly instructive example comes from research using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced models of PD, where chronic administration of monoacylglycerol lipase inhibitors was found to not only preserve dopaminergic neurons in the substantia nigra but also induce a distinctive microglial activation profile characterized by increased release of neurotrophic factors and decreased expression of classical inflammatory markers [459]