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Although there is little or no evidence of the effects of IUGR on vascular permeability in human neonates exposed to hypoxia, there is plenty of data obtained from different animal models (Clancy et al., 2015)

2024 Nov 15;51(1):1157

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For instance, depletion of mGSH results in Trx2 oxidation (Zhang et al., 2007), while hypercholesterolemic pigs with selective depletion of mGSH in heart mitochondria, exhibit decreased levels of the mitochondria-specific antioxidant enzymes such as SOD2, Trx2, and Prx3 (McCommis et al., 2011)

This is consistent with how these medications work in clinical settings