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Mitochondria consume over 90% of the oxygen used by cells which makes them especially vulnerable to oxidative free radical damage. Lactobacillus fermentum ME-3 provides additional antioxidant power because it also helps recycle antioxidants like vitamin C and vitamin E to their active forms
The Warburg effect A metabolic phenomenon driven by oncogenes, hypoxia and metabolic reprogramming in which cancer cells preferentially utilize glycolysis for energy production, even in the presence of oxygen, rather than relying on oxidative phosphorylation, which contributes to tumour growth and survival
It has been reported that these three compounds can enhance the contents of GSH and the activities of GSH-dependent antioxidant enzymes (GPX and GST) and reduce lipid peroxidation and cardiac damage mediated by DOX or isoproterenol (ISO) in the myocardium of rats, respectively [121, 129, 130]
Primer sequences used were as follows: GAPDH (F: CCTCGTCCCGTAGACAAAATG, R: TGAGGTCAATGAAGGGGTCGT);ANP (F: CCGATAGATCTGCCCTCTTGAA, R: GCTGTTGCAGCCTAGTCCACT);BNP (F: GGAGGCGAGACAAGGGAGAA, R: CCAGCGGTGACAGATAAAGGAA);-MHC (F: ATGAGGAGTAGCTCTTGTGCTACC, R: CCACCTAAAGGGCTGTTGC);All primers were synthesized by RiboBio (Guangzhou, China)
it acts as a buffer [4, 7]
