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In Long COVID and ME/CFS, it appears that this biological "circuit breaker" gets stuck in the off position long after the initial virus has been cleared, leaving the patient in a state of perpetual, severe energy depletion

The oxidation of the dihydrolipoyl moiety is catalyzed by a dihydrolipoamide dehydrogenase ( Figure 2 )

This design increases its half-life from minutes to several hours, allowing for greater receptor activation in tissues such as muscle and tendon

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These are hormones the immune system produces to help the body respond to allergy triggers