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CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
Lee and Padgett 2021 The study's limitations are genuine and must be stated: it is retrospective, uncontrolled, has no placebo arm, involves patients from a clinic with commercial interest in peptide therapy, and the sample size of 16 provides insufficient statistical power to draw definitive conclusions
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