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I decided I would start low, with 1mg and then see how I did before bumping up to 1.5 which is where I plan to stay

Another function of Tau is revealed by its presence in the nucleus, where it has been reported to play roles in heterochromatin organization and chromatin stability by binding and interaction with heterochromatin, as well as modifying the liquidliquid phase separation (LLPS) characteristic of chromatin components (Perez et al., 2009)

2001 Oct;25(10):1442-9

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This process involves using optimization algorithms like gradient descent, which iteratively modifies the models parameters to minimize the loss