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Supplementary searches were performed to identify overview of approved AOMs and background information

Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM

Nausea Vomiting Diarrhea Constipation Abdominal pain It is important to note that not everyone who takes semaglutide will experience side effects, and many people tolerate the medication well

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Prolonged activity, compatible with weekly dosing for improved patient convenience, was further achieved using slow release formulations or genetic fusion with a long half-life carrier protein as an antibody Fc or serum albumin 4