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The Medicines and Healthcare products Regulatory Agency (MHRA) and the electronic Medicines Compendium (eMC) do not list caffeine as a substance that should be avoided during Ozempic treatment, as confirmed in the interactions section of the SmPC
Clinical trials demonstrated that patients who followed gradual escalation experienced significantly fewer gastrointestinal side effects compared to those on faster schedules
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Further optimization was carried out by using an aeris wide pore XB-C8 (100 4.6mm), 3.6 m column thermostated at 40C with a mobile phase containing gradient program with Pump A: (acetonitrile: methanol (50:50) % v/v) and Pump B: (0.2% formic acid in milli Q water (v/v))
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