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They were housed under controlled environmental conditions at a constant temperature (25 2 C) with free access to a standard pellets diet and drinking water for 1 week before experimentation

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Furthermore, the cardiovascular disease prevention criteria resulted in the qualification of around 8.9 million adults aged 45 and older who met the eligibility criteria due to a high BMI and a history of major cardiovascular events, such as myocardial infarction or stroke