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This dual-use has earned semaglutide FDA approval for branded medications such as Ozempic, Wegovy, and Rybelsus
442 Tetrodecadazinone (a novel tetrodecamycin-pyridazinone hybrid) reduced the ECM proteins (fibronectin and collagen I) and -smooth muscle actin (-SMA) levels by regulating TGF-1/Smad2/3 signaling pathway
In vitro, rodent, or human
Clinical trials back this up: the STEP trials showed an average weight reduction of around 15% with Semaglutide, while the SURMOUNT trials reported up to 20% with Tirzepatide
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