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Several medication classes require consideration when prescribing semaglutide due to potential pharmacodynamic or absorption-related interactions

1 What the prescribing information does mention While theres no direct interaction with sertraline, the Wegovy SmPC does note that semaglutide delays gastric emptying, which could theoretically affect the absorption of some oral medications

In placebo group, 4.26% of patients experienced adverse events, including pyrosis, intense thirst and cholestasis, none of which was manifested as clinically relevant

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Patients should not self-prescribe high-dose vitamin E