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There are other important secondary outcomes, including the change in logMAR visual acuity, the development of center-involved diabetic macular edema (CI-DME) and the development of retinopathy, macular edema or vitreous hemorrhage requiring treatment

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Moreover, response to treatment might be highly heterogeneous

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The finding established that the GSH redox cycle is the primary intracellular antioxidant defence system in endothelial cells against peroxide-mediated oxidative stress, and remains a foundational reference for endothelial oxidative stress research using GSH manipulation