In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021
Yet, the few trials to date are promising
However, it is most often produced in the liver, in which the vital substance plays a central role
Reclaim Your Energy
La principale limite est la biodisponibilit : le glutathion est partiellement dgrad par les peptidases digestives et le mtabolisme hpatique de premier passage