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Unlike small molecule drugs, peptides have unique dose-response characteristics: U-shaped dose-response curves are common (BPC-157, GHK-Cu) higher doses may paradoxically reduce efficacy Narrow therapeutic windows in certain peptides (cagrilintide at high doses can cause significant GI effects in animal models) Non-linear bioavailability SC and IP absorption does not scale linearly with concentration
Wang J, Chen X, Su L, Li P, Liu B, Zhu Z
[Crossref] Lin J, Kelsberg G, Safranek S (2012) Clinical inquiry: Is high-dose oral B12 a safe and effective alternative to a B12 injection
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