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One potential factor contributing to these observations is that weight loss was a moving summary of the first 2 years, whereas drug exposure fell sharply thereafter
GLP-1R activation modulates postprandial insulin secretion, delays gastric emptying, and engages central appetite circuits
GLP-1s are more effective than other weight-loss drugs, resulting in more weight loss and keeping the weight off
The dosage and frequency of administration can impact the overall cost of treatment
Tissue-Level Interpretation Changes in body weight or adipose mass can result from altered food intake, hydration, lean mass, lipid synthesis, lipid mobilization, substrate oxidation, activity, thermogenesis, gastrointestinal effects, or tissue-specific adaptation
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