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Conversely, pathways enriched with downregulated DEGs encompassed PI3K-Akt signaling, calcium signaling, cytokine-cytokine receptor interaction, cell adhesion molecules, focal adhesion, phagosome, ECM-receptor interaction, cholinergic synapse, hematopoietic cell lineage, and malaria (Fig

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However, while these mechanisms have been proposed, the specific brain regions where GIP exerts its effects and the precise neural pathways involved remain under investigation

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Obesity has many metabolic consequences, such as type 2 diabetes mellitus (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), hypercholesterolemia, chronic kidney disease (CKD), cardiovascular disease, and an increased risk of certain types of cancer [2, 3]