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Acknowledgments Figure 1 was partly created using figures provided by Servier Medical Art ( licensed under a Creative Commons Attribution 4.0 Unported License

Some researchers believe these medications may reduce the wanting signal for pleasurable activities, including sex

Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]

Whatever the reason, understanding how to stop safely and manage withdrawal symptoms is crucial for maintaining long-term health goals