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Specifically, we first prepared the intermediates, including Fmoc-CS, Fmoc-HDA and Fmoc-BSO, by modifying the disulfide bond linker, the control non-GSH responsive carboncarbon bond linker and BSO with 9-fluorenylmethyloxycarbonyl (Fmoc) group and succinic anhydride through liquid-phase reactions (Additional file 1: Figs

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