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Ho pointed out that two previous trials with another GLP-1 agonist, semaglutide STEP HFpEF and STEP HFpEF Diabetes enrolled patients with HFpEF and obesity, and both showed improvements in quality of life, physical limitations, and weight loss, but they were not powered for a reduction in major clinical outcomes
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Similar content being viewed by others Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]
Aquaculture 59 , 177186 (1986)
[27] on the antidiabetogenic effect of intestinal factors, and in 1929 by Zung & La Barre [28] on the release of a substance from intestinal mucosa with properties to decrease glycaemia, signalled the start of the development of the incretin concept and the study of the relationships between the gut and the endocrine pancreas
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