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Unlike small molecule drugs, peptides have unique dose-response characteristics: U-shaped dose-response curves are common (BPC-157, GHK-Cu) higher doses may paradoxically reduce efficacy Narrow therapeutic windows in certain peptides (cagrilintide at high doses can cause significant GI effects in animal models) Non-linear bioavailability SC and IP absorption does not scale linearly with concentration

Two years ago, Jennifer Kirtley looked down at the scale and saw 328 pounds

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While Mounjaro has demonstrated impressive results, its not suitable for everyone

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